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1

Recent developments in grinding machines

Wegener, Konrad, Bleicher, Friedrich, Krajnik, Peter, Hoffmeister, Hans-Werner, Brecher, Christian

Journal:

CIRP Annals - Manufacturing Technology

Year:

2017

Language:

english

File:

PDF, 7.37 MB

english, 2017

2

Analysis of Double-Stranded Oligonucleotides by Electrospray Mass Spectrometry

Bayer, Ernst., Bauer, Tatjana., Schmeer, Karl., Bleicher, Konrad., Maier, Martin., Gaus, Hans-Joachim.

Journal:

Analytical Chemistry

Year:

1994

Language:

english

File:

PDF, 1006 KB

english, 1994

3

Functionalized Proline-Rich Peptides Bind the Bacterial Second Messenger c-di-GMP

Wennemers, Helma, Foletti, Carlotta, Kramer, Rolf, Mauser, Harald, Jenal, Urs, Bleicher, Konrad

Journal:

Angewandte Chemie

Year:

2018

Language:

english

File:

PDF, 1.09 MB

english, 2018

4

A guide to drug discovery: Hit and lead generation: beyond high-throughput screening

Bleicher, Konrad H., Böhm, Hans-Joachim, Müller, Klaus, Alanine, Alexander I.

Journal:

Nature Reviews Drug Discovery

Year:

2003

Language:

english

File:

PDF, 1.01 MB

english, 2003

5

Functionalized Proline-Rich Peptides Bind the Bacterial Second Messenger c-di-GMP

Wennemers, Helma, Foletti, Carlotta, Kramer, Rolf, Mauser, Harald, Jenal, Urs, Bleicher, Konrad

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 1.10 MB

english, 2018

6

Parallel Synthesis of Substituted Imidazoles from 1,2-Aminoalcohols.

Konrad H. Bleicher, Fernand Gerber, Yves Wuethrich, Alexander Alanine, Alfredo Capretta

Journal:

Year:

2003

File:

PDF, 136 KB

2003

7

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist

Song Feng, Minmin Yang, Zhenshan Zhang, Zhanguo Wang, Di Hong, Hans Richter, Gregory Martin Benson, Konrad Bleicher, Uwe Grether, Rainer E. Martin, Jean-Marc Plancher, Bernd Kuhn, Markus Georg Rudolph

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 431 KB

english, 2009

8

Parallel Solution- and Solid-Phase Synthesis of Spirohydantoin Derivatives as Neurokinin-1 Receptor Ligands.

Konrad H. Bleicher, Yves Wuethrich, Maxime De Boni, Sabine Kolczewski, Torsten Hoffmann, Andrew J. Sleight

Journal:

Year:

2003

Language:

english

File:

PDF, 101 KB

english, 2003

9

PhFl polystyrene: A new resin for solid phase organic synthesis

Konrad H. Bleicher, James R. Wareing

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 252 KB

english, 1998

10

Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors

Jürgen Wichmann, Konrad Bleicher, Eric Vieira, Thomas Woltering, Frédéric Knoflach, Vincent Mutel

Journal:

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

11

A Highly Efficient Synthesis Route for the Rapid Generation of 1,2,5,6-Tetrasubstituted Benzimidazoles

Duschmalé, Jörg, Woltering, Thomas, Bleicher, Konrad

Journal:

Year:

2008

Language:

english

File:

PDF, 92 KB

english, 2008

12

Multipin solid-phase synthesis of biaryls via Suzuki cross coupling reaction of aryltriflates

Christian Lutz, Konrad H. Bleicher

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 154 KB

english, 2002

13

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages

Duschmalé, Jörg, Hansen, Henrik Frydenlund, Duschmalé, Martina, Koller, Erich, Albaek, Nanna, Møller, Marianne Ravn, Jensen, Klaus, Koch, Troels, Wengel, Jesper, Bleicher, Konrad

Journal:

Nucleic Acids Research

Year:

2019

File:

PDF, 2.40 MB

2019

14

Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework

Stephan A. Ohnmacht, Tim Brenstrum, Konrad H. Bleicher, James McNulty, Alfredo Capretta

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 241 KB

english, 2004

15

Synthesis of 3′-PEG -Modified Oligonucleotides on PS -PEG Tentacle Polymers

Bayer, Ernst, Maier, Martin, Bleicher, Konrad, Gaus, Hans-Joachim

Journal:

Zeitschrift für Naturforschung B

Year:

1995

Language:

english

File:

PDF, 192 KB

english, 1995

16

Growth inhibition of pancreatic tumor cells by modified antisense oligodeoxynucleotides

Alexander Fiedler, Christoph Knorre, Yvonne Franke, Doris Henne-Bruns, Bernd Kremer, Jutta Lüttges, Martin Maier, Michael Gerster, Konrad Bleicher, Ernst Bayer, H. Kalthoff

Journal:

Langenbeck's Archives of Surgery

Year:

1998

Language:

english

File:

PDF, 231 KB

english, 1998

17

New phenylfluorenyl based linkers for solid phase synthesis

Konrad H Bleicher, Christian Lutz, Yves Wüthrich

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 119 KB

english, 2000

18

Parallel solution- and solid-phase synthesis of spiropyrrolo-Pyrroles as novel neurokinin receptor ligands

Konrad H Bleicher, Yves Wüthrich, Geo Adam, Torsten Hoffmann, Andrew J Sleight

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 131 KB

english, 2002

19

Chemogenomics: Bridging a Drug Discovery Gap

Bleicher, Konrad

Journal:

Current Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 173 KB

english, 2002

20

Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Alig, Leo, Alsenz, Jochem, Andjelkovic, Mirjana, Bendels, Stefanie, Bénardeau, Agnès, Bleicher, Konrad, Bourson, Anne, David-Pierson, Pascale, Guba, Wolfgang, Hildbrand, Stefan, Kube, Dagmar, Lübbers,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.56 MB

english, 2008

21

Identification of novel cannabinoid receptor ligands via evolutionary de novo design and rapid parallel synthesis

Mark Rogers-Evans, Alexander I. Alanine, Konrad H. Bleicher, Dagmar Kube, Gisbert Schneider

Journal:

Molecular Informatics

Year:

2004

Language:

english

File:

PDF, 149 KB

english, 2004

22

Parallel solution- and solid-Phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands

Konrad H. Bleicher, Yves Wüthrich, Maxime De Boni, Sabine Kolczewski, Torsten Hoffmann, Andrew J. Sleight

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

23

Improved Conditions for Solid Phase Synthesis of Oligonucleotides on PS-PEG Copolymers

Bayer, Ernst, Bleicher, Konrad, Maier, Martin

Journal:

Zeitschrift für Naturforschung B

Year:

1995

Language:

english

File:

PDF, 4.23 MB

english, 1995

24

Design and Synthesis of Nucleoproline Amino Acids for the Straightforward Preparation of Chiral and Conformationally Constrained Nucleopeptides

Kramer, Rolf A., Bleicher, Konrad H., Wennemers, Helma

Journal:

Helvetica Chimica Acta

Year:

2012

Language:

english

File:

PDF, 333 KB

english, 2012

25

Diffusion Edited NMR: Screening Compound Mixtures by Affinity NMR to Detect Binding Ligands to Vancomycin

Bleicher, Konrad, Lin, Mengfen, Shapiro, Michael J., Wareing, James R.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 99 KB

english, 1998

26

Various factors influencing the signal intensity of oligonucleotides in electrospray mass spectrometry

Konrad Bleicher, Ernst Bayer

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Year:

1994

Language:

english

File:

PDF, 271 KB

english, 1994

27

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Roche, Olivier, Schneider, Petra, Zuegge, Jochen, Guba, Wolfgang, Kansy, Manfred, Alanine, Alexander, Bleicher, Konrad, Danel, Franck, Gutknecht, Eva-Maria, Rogers-Evans, Mark, Neidhart, Werner, Stald

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 134 KB

english, 2002

28

PhFl acetic acid: A new linker for solid phase organic synthesis

Konrad H. Bleicher, James R. Wareing

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 294 KB

english, 1998

29

Lead Generation: Sowing the Seeds for Future Success

Bleicher, Konrad H., Nettekoven, Matthias, Peters, Jens-Uwe, Wyler, René

Journal:

CHIMIA International Journal for Chemistry

Year:

2004

Language:

english

File:

PDF, 1.22 MB

english, 2004

30

Parallel Solution- and Solid-Phase Synthesis of Spiropyrrolo-Pyrroles as Novel Neurokinin Receptor Ligands.

Konrad H. Bleicher, Yves Wuethrich, Geo Adam, Torsten Hoffmann, Andrew J. Sleight

Journal:

Year:

2003

File:

PDF, 149 KB

2003

31

Ligand identification for G-protein-coupled receptors: a lead generation perspective

Konrad H Bleicher, Luke G Green, Rainer E Martin, Mark Rogers-Evans

Journal:

Current Opinion in Chemical Biology

Year:

2004

Language:

english

File:

PDF, 184 KB

english, 2004

32

Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

Konrad H. Bleicher, Fernand Gerber, Yves Wüthrich, Alexander Alanine, Alfredo Capretta

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

33

Solid Phase Synthesis of β-Peptides via Arndt-Eistert Homologation of Fmoc-Protected Amino Acid Diazoketones

Roger E Marti, Konrad H Bleicher, Kenneth W Bair

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 528 KB

english, 1997

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